1.
Bioorg Med Chem
; 20(22): 6613-20, 2012 Nov 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23063517
RESUMO
The 4-isoxazolyl-dihydropyridines (IDHPs) exhibit inhibition of the multidrug-resistance transporter (MDR-1), and exhibit an SAR distinct from their activity at voltage gated calcium channels (VGCC). Among the four most active IDHPs, three were branched at C-5 of the isoxazole, including the most active analog, 1k.